Life Sciences Transformational R&D Investment Fund (TRIF) Pilot

Document research last revised 2026-08-24.

Grant Name

Life Sciences Transformational R&D Investment Fund (TRIF) Pilot

Maximum Grant

£25 million. This is explicitly stated in the subsidy-control section. (Find a Grant)

Financial Requirements

Applicants must provide two years of audited accounts for the applicant company or parent entity. If these are unavailable, the applicant must demonstrate that the remaining project funding has been secured. (Find a Grant)

Track Record Requirement

Applicants must demonstrate a track record of successfully developing or manufacturing medicines or medical devices in the UK or internationally. (Find a Grant)

Eligible Projects

Projects must have total costs, including eligible capital and non-capital costs, of at least £100 million, be located in the UK, be primarily capital investment, be a single-company investment and be dependent on the grant to proceed. (Find a Grant)

Grant Dependency

Projects that would otherwise not occur, would be delayed by three years or more, scaled down, or relocated overseas without the grant may be eligible. (Find a Grant)

Eligible R&D Areas

Human medicines, medical diagnostics and MedTech products. Human medicines include APIs and finished drug products intended for human use. (Find a Grant)

Objectives

Objective 1: Health resilience and innovation. Objective 2: Creating economic opportunity through GVA, high-wage/high-skilled jobs and R&D spillover benefits. (Find a Grant)

Application Process

Three sections: Application Form 1/EOI, Objective 1 health resilience and innovation assessment including a panel interview, and Application Form 2 followed by financial/economic assessment and due diligence. (Find a Grant)

Panel Interview

Successful Stage 1 applicants give a 10-minute presentation, followed by a short Q&A. Independent experts assess health resilience, innovation, project viability and deliverability. (Find a Grant)

Panel Frequency

Independent panel interviews take place monthly for successful Stage 1 applications. (Find a Grant)

Due Diligence

The assessment considers value for money, subsidy-control compliance, what would happen without the grant, project deliverability, employment outputs and the applicant's ability to finance the project. (Find a Grant)

Regulatory Requirements

Funding can support MHRA-licensed medicines, medical and diagnostic devices registered with the MHRA, and products in development where UK approval to market/manufacture is intended. Relevant manufacturing facilities must meet GMP requirements. (Find a Grant)

Clinical Trial Requirements

Projects involving investigational medicinal products or medical devices for clinical trials must comply with applicable requirements, including Clinical Trials Authorisation (CTA) and Good Clinical Practice (GCP). (Find a Grant)

Subsidy Control

Awards are made under Section 7 or 8 of the Industrial Development Act 1982 and must comply with applicable UK subsidy-control requirements. (Find a Grant)

Northern Ireland

Applications within the scope of the Windsor Framework may be subject to European Commission State aid rules under the UK-EU Trade and Cooperation Agreement. Other applications are subject to the UK subsidy regime under the Subsidy Control Act 2022. (Find a Grant)

Important Note

DSIT reserves the right to offer less than the amount requested. Recovery of funds may be required if subsidy-control requirements are not complied with. (Find a Grant)

Application Contact

TRIF@officeforlifesciences.gov.uk (Find a Grant)

Application deadline in source document

31 March 2028, 11:59pm (Find a Grant)

Official source

Read the funding authority guidance